Background:

HRSP12 (heat-responsive protein 12), also known as PSP, P14.5 or UK114, is a 137 amino acid protein that belongs to the UPF0076 (UK114) family and is expressed primarily in liver and kidney. Localized to the cytoplasm in highly differentiated cells and to the nucleus in less differentiated cells, HRSP12 functions as an endoribonuclease that inhibits translation by cleaving mRNA. Specifically, HRSP12 cleaves phosphodiester bonds in single-stranded mRNA, thereby breaking the mRNA and preventing protein synthesis. HRSP12 exists as a homotrimer and may be a tumor antigen involved in malignant neoplasms. This suggests a possible role in carcinogenesis.

Specificity:

HRSP12 polyclonal antibody detects endogenous levels of HRSP12 protein.

Alternative names:

Ribonuclease UK114; p14.5; Heat-responsive protein 12; UK114 antigen homolog; PSP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human HRSP12.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 14.5 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com