Background:

UQCRC1, or Ubiquinol-cytochrome-c reductase complex core protein 1, is a core subunit of the mitochondrial respiratory complex III. It is the largest nuclear encoded subunit of the complex. UQCRC1 plays a key role in mitochondria-to-nucleus retrograde response and is involved in the mitochondrial proton gradient formation. It has also shown to interact with Nogo, an inhibitor of neurite growth after spinal cord injury. UQCRC1 has been found at high expression levels in breast and ovarian tumors, positively correlating with Cox-2 expression. Transcription of UQCRC1 is repressed by the nuclear protein methyl-CpG-binding protein-2 (MeCP2).

Specificity:

UQCRC1 polyclonal antibody detects endogenous levels of UQCRC1 protein.

Alternative names:

QCR1; UQCR1; D3S3191;

Species reactivity:

Human,Mouse,Rat,Monkey

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human UQCRC1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 53 kDa

Applications:

WB IHC

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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