Background:

CIRP, also known as CIRBP (cold inducible RNA binding protein) or A18HNRNP, is a 172 amino acid protein that localizes to the nucleus and contains one RRM (RNA recognition motif) domain. Expressed ubiquitously, CIRP is thought to play an essential role in the suppression of cellular proliferation in response to UV irradiation or extreme cold. Human CIRP, which may be involved in the pathogenesis of endometrial carcinoma, shares 95% sequence identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding CIRP maps to human chromosome 19, which is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).

Specificity:

CIRBP polyclonal antibody detects endogenous levels of CIRBP protein.

Alternative names:

Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP; CIRBP; A18HNRNP; CIRP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human CIRBP.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 19 kDa

Applications:

WB IHC IF

Usage:

WB: 1:500~1:2000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com