Background:

ß-TrCP (beta-tranducin repeats containing protein), also designated E3RSIkB or FWD1, and HOS (homologous to Slimb) are F-box proteins that function as substrate recognition subunits of ubiquitin ligases. HOS and ß-TrCP differ in their amino terminal regions, but exhibit high homology within the F-box and WD40 repeat-containing regions. ß-TrCP mediates ubiquitin/proteasome-dependent degradation of CD4 and ubiquitination of various proteins including IkB and ß-catenin. HOS has also been shown to regulate the degradation of IkB and ß-catenin in a similar manner.

Specificity:

BTRC polyclonal antibody detects endogenous levels of BTRC protein.

Alternative names:

Beta transducin repeat containing E3 ubiquitin protein ligase; beta TrCP1; beta-transducin repeat containing; BETA-TRCP; betaTrCP; BTRC; bTrCP; bTrCP1; E3RSIkappaB; F box and WD repeat protein 1B; F box and WD repeats protein beta TrCP; F-box and WD repeats protein beta-TrCP; F-box/WD repeat protein 1A; F-box/WD repeat-containing protein 1A; FBW1A; FBW1A; FBXW1; FBXW1A; FWD1; HOS; mKIAA4123; pIkappaBalpha-E3 receptor subunit; Slimb;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human BTRC.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 68 kDa

Applications:

WB,IHC,IF

Usage:

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com