Background:

The dynactin complex is a macromolecular complex that consists of 10-11 distinct subunits. This complex is critical for the function of dynein, a molecular motor protein. Dynactin plays a role in ER to Golgi transport, spindle formation, chromosome movement, axon guidance, nuclear positioning and the centripetal movement of lysosomes and endosomes. Centractin is a subunit of the dynactin complex that exists in multiple isoforms. The α isoform, also known as actin-related protein 1 homolog A (Arp1) and previously referred to as centractin, is the most abundant isoform in the dynactin complex. The β isoform, also known as actin-related protein 1 homolog B, shares 90% identity with the α isoform. The two isoforms, α and β, are expressed at a ratio of 15:1 respectively. The backbone filament structure of the dynactin complex (important for the arrangement of other complex proteins) is composed of 9-11 subunits of α/β-centractin.

Specificity:

ACTR1A polyclonal antibody detects endogenous levels of ACTR1A protein.

Alternative names:

Alpha-centractin; Centractin; ARP1; Actin-RPV; Centrosome-associated actin homolog; ACTR1A; CTRN1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human ACTR1A.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 43 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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