Background:

β-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. The family of β-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many β-defensins also are involved in sperm maturation and capacitation. β-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, β-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other β-defensins, it does not appear to be regulated by androgens.

Specificity:

DEFB121 polyclonal antibody detects endogenous levels of DEFB1211 protein.

Alternative names:

beta 121; Beta-defensin 121; Beta-defensin 21; DB121; DEFB-21; DEFB121; Defensin; defensin; beta 121; defensin; beta 21; ESC42RELC;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human DEFB121.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 8 kDa

Applications:

IHC IF

Usage:

IHC 1:50 - 1:100 IF 1:50 - 1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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