Background:

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.

Specificity:

RASSF1 polyclonal antibody detects endogenous levels of RASSF1 protein.

Alternative names:

123F2; Cardiac specific ras association domain family 1 protein; NORE2A; Pancreas specific ras association domain family 1 protein; Ras association domain containing protein 1; Ras association domain family 1; Ras association domain family 1A; Ras association domain family protein 1; Ras association domain-containing protein 1; Ras association RalGDS/AF6 domain family 1; RASF1; RASSF 1; RASSF 1a; RASSF1; RASSF1A; RASSF1A isoform; RDA 32; RDA32; REH3P21; Tumor suppressor protein RDA32;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human RASSF1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 39 kDa

Applications:

WB IF

Usage:

WB: 1:500~1:2000 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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