Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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ALDH18A1 polyclonal antibody BS61819

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Specifications

size	50ul/100ul

Background:

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during the detoxification of alcohol-derived acetaldehyde, lipid peroxidation, and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH18A1 (aldehyde dehydrogenase 18 family member A1), also known as GSAS (glutamate γ-semialdehyde synthetase), P5CS (δ1- pyrroline-5-carboxylate synthetase) or PYCS, is the major enzyme involved in proline, arginine and ornithine biosynthesis. Localizing to the inner mitochondrial membrane, ALDH18A1 catalyzes the reduction of glutamate to δ1- pyrroline-5-carboxylate. Due to alternative splicing events, two isoforms exist for ALDH18A1, differing by only two amino acids. The longer isoform is widely expressed while the shorter isoform predominantly functions in the gut. A mutation in the gene encoding ALDH18A1 results in P5CS deficiency, a disease characterized by progressive joint laxity, neurodegeneration, bilateral subcapsular cataracts and skin hyperelasticity.

Specificity:

ALDH18A1 pAb detects endogenous levels of ALDH18A1 protein.

Alternative names:

Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; Glutamate 5-kinase; GK; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; ALDH18A1; GSAS; P5CS; PYCS

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to Human ALDH18A1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 87 kDa

Applications:

Usage:

WB: 1:2000~1:10000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com