Background:

The transient receptor potential cation channel subfamily V member 3 (TRPV3 or VRL3) is a widely expressed ligand-gated ion channel protein that acts in temperature detection between 22º C and 40º C. Related transient receptor proteins (TRP) respond to different temperature ranges; TRPA1 responds to cold temperatures and TRPM1 to cool, while warmer temperatures elicit response from TRPV3 and TRPV4. Noxious heat or painful temperatures correlate with TRPM8 and TRPV1 activity. TRPV3 is found in association with TRPV1 (VR1) and is thought to modulate activity of this noxious heat-responsive protein. Increased TRPV1 and TRPV3 protein expression is correlated with nervous injury, while reduced expression of both may be see in cases of diabetic skin neuropathy. Recent evidence implicates TRPV3 in pruritic dermatitis, or itching associated with eczema and related skin disorders.

Specificity:

TRPV3 polyclonal antibody detects endogenous levels of TRPV3 protein.

Alternative names:

Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3; TRPV3

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 330-380 of Human TRPV3.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 98 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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