Background:

Cathepsin H (also designated N-benzoylarginine-β-naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfidelinked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full-length and truncated cathepsin H [12 amino acid deletion in the signal peptide region (CTSH∆10-21)] are expressed in prostate tissues, LNCaP, PC-3 and DU-145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein-B (SP-B) peptide.

Specificity:

Cathepsin H polyclonal antibody detects endogenous levels of Cathepsin H protein.

Alternative names:

Pro-cathepsin H; Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; CTSH; CPSB

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 100-150 of Human Cathepsin H.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 37 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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