Background:

Acrosin, a member of the peptidase S1 family, is a major protease present in the acrosome of mature mammalian spermatozoa. Acrosin is a typical serine proteinase with trypsin-like cleavage specificity. The zymogen form, proacrosin, is the precursor of Acrosin synthesized only in the postmeiotic stages of spermatogenesis. The active enzyme functions in the lysis of the zona pellucida, allowing the penetration of sperm through the innermost glycoprotein layers of the ovum.

Specificity:

ACR polyclonal antibody detects endogenous levels of ACR protein.

Alternative names:

Acrosin; Acrosin light chain; Acrosin heavy chain; ACR; ACRS

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 1-50 of Human ACR.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 46 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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