Background:

The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM68 (tripartite motif-containing protein 68), also known as RNF137 (RING finger protein 137) or SS56, is a 485 amino acid protein that localizes to the perinuclear region of the cytoplasm. Expressed in a variety of tissues with higher expression in prostate, spleen and fetal liver, TRIM68 associates with androgen receptor (AR) and, via this interaction, enhances the transcriptional activity of AR. TRIM68 is found in various cancers, including prostate cancer cells, and is thought to be a therapeutic target for the detection and treatment of prostate cancer. Additionally, TRIM68 is a target of the autoimmune response exhibited in systemic lupus erythematosus (SLE), primary Sjoegren syndrome and HIV-1 infection.

Specificity:

TRIM68 polyclonal antibody detects endogenous levels of TRIM68 protein.

Alternative names:

E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68; TRIM68; GC109; RNF137; SS56

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 120-170 of Human TRIM68.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 68 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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