Background:

Na+/H+ exchangers 1-8, also designated Na+/H+ antiporters or NHE-1-8, are integral membrane proteins expressed in most mammalian tissues where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, NHE isoforms 2-8 have distinct tissue and cell type dependent expression and inhibitory characteristics. NHE-8 is a 575 amino acid protein that localizes apically in intestinal epithelial cells. Expression of NHE-8 is higher in young mammals than adults. NHE-8 gene and protein expression are highly regulated during ontogeny; this protein may play an important role in intestinal Na+ absorption during early mammalian life.

Specificity:

SLC9A8 polyclonal antibody detects endogenous levels of SLC9A8 protein.

Alternative names:

Sodium/hydrogen exchanger 8; Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8; SLC9A8; KIAA0939; NHE8

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 450-500 of Human SLC9A8.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 65 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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