Background:

Heterogeneous nuclear ribonucleoprotein L-like (hnRNP LL) is a nuclear RNA-binding protein that shares 69% amino acid homology with hnRNP L, a component of the hnRNP complex that regulates mRNA formation, packaging, and processing. hnRNP LL is induced in activated T cells and functions as a critical regulator of alternative splicing of CD45, a tyrosine phosphatase crucial for T cell development and activation. hnRNP LL also regulates the splicing of CD44 and Stat5a. The four isoforms of hnRNP LL are generated by alternative splicing and are widely expressed in human tissues.

Specificity:

HNRPLL polyclonal antibody detects endogenous levels of HNRPLL protein.

Alternative names:

Heterogeneous nuclear ribonucleoprotein L-like; hnRNPLL; Stromal RNA-regulating factor; HNRNPLL; HNRPLL; SRRF; BLOCK24

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding Human HNRPLL.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 60 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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