Background:

ADP-ribosylation factors (ARFs) are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL2 (ADP-ribosylation factor-like protein 2) functions as a component of a secretory pathway that is involved in the calcium-dependent release of acetylcholine. Additionally, ARL2 plays a role in the folding of tubule proteins, thereby playing an important role in microtubule dynamics and cell cycle progression. BART1 (Binder of ARL2 protein 1), also known as ARL2BP (ADP-ribosylation factor-like protein 2-binding protein), is a 163 amino acid protein that interacts with GTP-bound ARL2 complexes and therefore may play a role in modulating ARL2 activity. Though predominantly cytosolic, BART1 can enter the mitochondria and bind the adenine nucleotide transporter when bound to ARL2. There are two isoforms of BART1 that are produced as a result of alternative splicing events.

Specificity:

ARL2BP polyclonal antibody detects endogenous levels of ARL2BP protein.

Alternative names:

ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; ARL2-binding protein; Binder of ARF2 protein 1

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 104-148 of Human ARL2BP.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 100% (by SDS-PAGE).

Molecular weight:

~ 18 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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