Background:

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. α-protein kinase 1, also known as ALPK1, LAK or KIAA1527, is a 1,244 amino acid protein that contains one α-type protein kinase domain and belongs to the protein kinase superfamily. Expressed at high levels in liver, α-protein kinase 1 recognizes and phosphorylates specific phosphorylation sites that are surrounded by peptides which have an å-helical conformation. One of the targets of å-protein kinase 1 is Myosin I and, via its ability to phosphorylate Myosin I, α-protein kinase 1 is thought to play an important role in the apical trafficking of vesicles carrying raft-associated sucrase-isomaltase (SI).

Specificity:

ALPK1 polyclonal antibody detects endogenous levels of ALPK1 protein.

Alternative names:

Alpha-protein kinase 1; Chromosome 4 kinase; Lymphocyte alpha-protein kinase

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 11-55 of Human ALPK1

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Molecular weight:

~ 139 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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