Background:

CGR19 (Cell growth regulatory gene 19 protein), also known as Cell growth regulator with RING finger domain protein 1 and RING finger protein 197, is a 332 amino acid protein contains one RING-type zinc finger domain. CGR19 is ubiquitously expressed, with highest levels found in testis. It has been suggested that CGR19 plays a role in regulating the cell cycle because it inhibits growth in several cell lines. The gene encoding CGR19 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Specificity:

CGRRF1 polyclonal antibody detects endogenous levels of CGRRF1 protein.

Alternative names:

Cell growth regulator with RING finger domain protein 1; Cell growth regulatory gene 19 protein; RING finger protein 197

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 288-332 of Human CGRRF1

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Molecular weight:

~ 36, 38 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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