Background:

Mitochondria have their own translation machinery for production of thirteen proteins that are required for oxidative phosphorylation. MRP-L11 (39S ribosomal protein L11, mitochondrial), also known as CGI-113, is a 192 amino acid protein that is a component of the large ribosomal subunit of the mitochondria. MRP-L11 is one of the 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome. The gene encoding MRP-L11 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Specificity:

MRPL11 polyclonal antibody detects endogenous levels of MRPL11 protein.

Alternative names:

39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 28-72 of Human MRPL11.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Molecular weight:

~ 20 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com