Background:

DUS2L (tRNA-dihydrouridine synthase 2-like), also known as URLC8 (upregulated in lung cancer protein 8) or SMM1, is a 493 amino acid member of the DUS protein family. Localized to cytoplasm and endoplasmic reticulum, DUS2L uses FAD as a cofactor to catalyze the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. DUS2L contains one DRBM (double-stranded RNA-binding) domain and has been found to interact with ProRS. DUS2L is upregulated in most lung cancer cells and has weak expression in normal heart, skeletal muscle and placenta. The gene that encodes DUS2L maps to human chromosome 16q22.1 and murine chromosome 8 D3.

Specificity:

DUS2L polyclonal antibody detects endogenous levels of DUS2L protein.

Alternative names:

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase 2; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 441-485 of Human DUS2L.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 55 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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