Background:

HAPLN4 (Hyaluronan and proteoglycan link protein 4) is a 360 amino acid protein encoded by the human gene HAPLN4. HAPLN4 belongs to the HAPLN family and contains 1 Ig-like C2-type (immunoglobulin-like) domain and two Link domains. HAPLN4 mediates the binding of complexes containing hyaluronic acid. HAPLN2 mediates a firm binding of versican V2 to hyaluronic acid. HAPLN4 is believed to play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS), which facilitates neuronal conduction and general structural stabilization. HAPLN4 may also be involved in the formation of extracellular matrices contributing to perineuronal nets and facilitate the understanding of a functional role of these extracellular matrices. HAPLN4 is widely expressed with highest levels in spleen and placenta.

Specificity:

HAPLN4 polyclonal antibody detects endogenous levels of HAPLN4 protein.

Alternative names:

Hyaluronan and proteoglycan link protein 4; Brain link protein 2; HAPLN4; BRAL2, KIAA1926

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding toamino acids 114-159 Human HAPLN4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 42 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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