Background:

GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.RN-tre (related to the N-terminus of tre), also known as USP6NL(USP6 Nterminal like) or TRE2NL, is an 828 amino acid protein thatcontains one RabGAP TBC domain. Expressed in awide variety of tissues, RN-tre functions as a GTPase-activating protein for Rab 5A and isthought to be involved in receptor trafficking, aswell asin the inhibition of EGFR internalization. In response to DNA damage, RN-tre may be phosphorylated by ATM or ATR. The gene encoding RN-tre mapsto human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Specificity:

USP6NL polyclonal antibody detects endogenous levels of USP6NL protein.

Alternative names:

USP6 N-terminal-like protein; Related to the N-terminus of tre; RN-tre; USP6NL; KIAA0019

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 446-491 of Human USP6NL.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 86 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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