Background:

STAMP2 (SixTransMembrane protein of prostate 2), also known as STEAP4 (STEAP family member 4), TIARP or TNFAIP9, is a 459 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one ferric oxidoreductase domain. Expressed ubiquitously with highest expression in lung, prostate, placenta and heart, STAMP2 functions as a metalloreductase that uses FAD as a cofactor to reduce both Fe3+ and Cu2+ to Fe2+ and Cu1+, respectively. Multiple isoforms of STAMP2 exist due to alternative splicing events. The gene encoding STAMP2 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

Specificity:

STEAP4 polyclonal antibody detects endogenous levels of STEAP4 protein.

Alternative names:

Metalloreductase STEAP4; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9; STEAP4; STAMP2; TNFAIP9

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 195-240 of Human STEAP4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 52 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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