Background:

SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellular signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis.

Specificity:

SH2D4A polyclonal antibody detects endogenous levels of SH2D4A protein.

Alternative names:

SH2 domain-containing protein 4A; Protein SH(2)A; Protein phosphatase 1 regulatory subunit 38; SH2D4A; PPP1R38; SH2A

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human SH2D4A.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 52 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com