Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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CCP110 polyclonal antibody BS61151

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Specifications

size	50ul/100ul

Background:

Centrosome duplication and separation are linked inextricably to certain cell cycle events, specifically, activation of cyclin-dependent kinases of cyclin-dependent kinases. CP110 (centrosomal protein of 110 kDa) is a 991 amino acid cell cycle-dependent CDK substrate that regulates centrosome duplication. Localizing to the centrosome, CP110 contains ten putative CDK2 phosphorylation sites, two cyclin-binding domains and two degradation motifs. CP110 is highly expressed in testis with much lower expression in all other tissues. CP110 interacts with Ca2+-binding proteins including calmodulin (CaM) and centrin, to regulate genome stability and progression through cytokinesis. During the formation of cylindrical centrioles, it is suggested that CP110 acts as a distal end-capping protein thereby limiting the elongation of newly formed centrioles. Existing as two alternatively spliced isoforms, CP110 is observed at highest levels during the S phase of the cell cycle. CP110 becomes phosphorylated by Cdks (cyclin-dependent kinases) and is encoded by a gene located on human chromosome 16p12.3.

Specificity:

CCP110 polyclonal antibody detects endogenous levels of CCP110 protein.

Alternative names:

Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110; CCP110; CEP110; CP110; KIAA0419

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human CCP110.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 130 kDa

Applications:

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com