Background:

DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis and cellular growth and division. DDX24 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 24) is an 859 amino acid protein that contains one helicase C-terminal domain and one helicase ATP-binding domain. Expressed ubiquitously with highest levels in brain and heart, DDX24 functions as an ATP-dependent RNA helicase that is subject to DNA damage-dependent phosphorylation. Human DDX24 shares 79% sequence similarity with its mouse counterpart, suggesting a conserved role between species.

Specificity:

DDX24 polyclonal antibody detects endogenous levels of DDX24 protein.

Alternative names:

ATP-dependent RNA helicase DDX24 (EC:3.6.4.13); DEAD box protein 24; DDX24

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human DDX24.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 90 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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