Background:

Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events). CYP26C1 (cytochrome P450, family 26, subfamily C, polypeptide 1) is a 522 amino acid single-pass membrane protein expressed in most tissues at very low levels. Belonging to the cytochrome P450 family, CYP26C1 uses heme groups as cofactors and is induced by retinoic acid. CYP26C1 participates in the retinoic metabolism and acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer, 9-cis-RA.

Specificity:

CYP26C1 polyclonal antibody detects endogenous levels of CYP26C1 protein.

Alternative names:

Cytochrome P450 26C1 (EC:1.14.-.-); CYP26C1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human CYP26C1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 57 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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