Background:

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. The proinflammatory cytokine Interleukin 17D (IL-17D), also known as IL-27, is the largest member of the IL-17 family of cytokines. It is produced by CD4+ T cells and is predominantly expressed in brain, lung, heart, adipose tissue, pancreas and skeletal muscle. IL-17D regulates the production of other cytokines in endothelial cells, including IL-6, IL-8 and GM-CSF. It may play a role in the activation of the endothelium, which is the site of attachment for migrating immune cells. In addition, IL-17D may play a role in the amplification of a local immune response.

Specificity:

IL17D polyclonal antibody detects endogenous levels of IL17D protein.

Alternative names:

Interleukin-17D; IL-17D; Interleukin-27; IL-27; IL17D; IL27

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human IL17D.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 22 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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