Background:

Decoy receptors are structurally incapable of activating signaling pathways, but act as anti-inflammatory agents by sequestering agonists for actual signaling complexes. The type II IL-1 receptor (IL-1RII) acts as a decoy receptor for the chemokine interleukin-1 (IL-1). Additionally, the soluble form of IL-1R accessory protein (IL-1R AcP) increases the affinity of binding of IL-1α and IL-1β to IL-1RII 100-fold, but does not increase the affinity for another antiinflammatory agent, IL-1R antagonist (IL-1Ra). The end result is a complex regulatory mechanism for IL-1 activated inflammation, whereby dexamethasone and other molecules inducing IL-1RII, function in an immunosupressive and anti-inflammatory manner.

Specificity:

IL1R2 polyclonal antibody detects endogenous levels of IL1R2 protein.

Alternative names:

Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD121b; Interleukin-1 receptor type 2, membrane form; mIL-1R2; mIL-1RII; Interleukin-1 receptor type 2, soluble form; sIL-1R2; sIL-1RII; IL1R2; IL1RB

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human IL1R2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 45 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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