Background:

CD101 is a disulfide-linked homodimeric polypeptide. The gene encoding the CD101 antigen is identical to the gene encoding for the V7 antigen, which corresponds to a type I transmembrane protein containing seven Ig-like loops in its extracellular domain. CD101 may play an important regulatory role during T cell activation and may also be useful in combination with other markers for the diagnosis of LCH (Langerhans cell histiocytosis). CD101 is expressed on monocytes, granulocytes, dendritic cells and at low levels on a subset of peripheral T-cells comprising both CD4+ and CD8+, as well as both CD45RA+ and CD45RO+ cells. Expression of CD101 increases upon T cell activation.

Specificity:

CD101 polyclonal antibody detects endogenous levels of CD101 protein.

Alternative names:

Immunoglobulin superfamily member 2; IgSF2; Cell surface glycoprotein V7; Glu-Trp-Ile EWI motif-containing protein 101; EWI-101; CD101; CD101; EWI101; IGSF2; V7

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human CD101.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 115 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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