Background:

Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. The Synaptotagmin family of proteins share a common domain structure that consists of a transmembrane domain and a cytoplasmic region composed of two C2 domains. Synaptotagmin VIII, also known as SYT8, is a 401 amino acid single-pass type III membrane protein belonging to the Synaptotagmin family. Containing two C2 domains, Synaptotagmin VIII exists as a homodimer or homooligomer. Synaptotagmin VIII exists as two alternatively spliced isoforms, isoform 1 and isoform 4. Synaptotagmin VIII isoform 4 is thought to participate in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

Specificity:

SYT8 polyclonal antibody detects endogenous levels of SYT8 protein.

Alternative names:

Synaptotagmin-8; Synaptotagmin VIII; SytVIII; SYT8

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human SYT8.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 18 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:204

Storage:

Store at 4°C short term. Aliquot and store at -24°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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