Background:

The PR-domain containing proteins (PRDMs) have a common involvement in the modulation of gene activities. A PR-domain family member usually produces two products, which differ by the presence or absence of the PR domain. The PR-plus product is underexpressed or disrupted, whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, which is a result of either genetic or epigenetic events, appears to be a determining cause of malignancy. PRDM10 (PR domain containing 10), also known as PFM7 or TRIS, is a 1,147 amino acid protein that contains ten C2H2-type zinc fingers and one SET domain. Existing as six alternatively spliced isoforms, PRDM10 localizes nucleus and may be involved in transcriptional regulation. PRDM10 may also play a role in the development of the central nerve system, as well as in the pathogenesis of neuronal storage disease.

Specificity:

PRDM10 polyclonal antibody detects endogenous levels of PRDM10 protein.

Alternative names:

PR domain zinc finger protein 10; PR domain-containing protein 10; Tristanin; PRDM10; KIAA1231; PFM7; TRIS

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human PRDM10

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 130 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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