Background:

Integrins are heterodimers composed of noncovalently associated transmembrane å and ∫ subunits. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin å8 is expressed in contractile interstitial cells and smooth muscle cells and is upregulated in lung injury. Integrin å8 is also a marker for smooth muscle cells, expressed as early as alpha smooth muscle actin. The Integrin å8 chain is expressed in the glomerulus exclusively by mesangial cells and may play an important role for maintaining tissue integrity in the glomerulus during glomerular injury.

Specificity:

ITGA8 polyclonal antibody detects endogenous levels of ITGA8 protein.

Alternative names:

Integrin alpha-8; ITGA8

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human ITGA8.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 117 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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