Background:

ApoB48R (apolipoprotein B48 receptor), also known as apolipoprotein B-100 receptor, is a 1,088 amino acid protein that functions as a macrophage receptor by binding to apoB of dietary triglyceride-rich lipoproteins or to a similar apoB-like domain in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). ApoB48R may contribute necessary lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. Significantly elevated plasma triglyceride levels may cause apoB48R to be a factor in foam cell formation, endothelial dysfunction and atherothrombogenesis. ApoB48R also mediates the swift, high-affinity uptake of chylomicrons, HTG-VLDL and trypsinized VLDL lacking apoE in in vitro macrophages. Conserved in chimpanzee, dog, cow, mouse and rat, apoB48R is ubiquitously expressed in all tissues, except skeletal muscle, with high expression in lung and placenta, and low expression in brain and heart. ApoB48R is encoded by a gene that maps to human chromosome 16p11.2 and exists as three alternatively spliced isoforms.

Specificity:

APOBR polyclonal antibody detects endogenous levels of APOBR protein.

Alternative names:

Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; apoB-48R; APOBR; APOB48R

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human APOBR

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 115 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com