Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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CX3CR1 polyclonal antibody BS60627

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Specifications

size	50ul/100ul

Background:

Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Fractalkine, also designated CX3CL1, contains the CX3C motif and is widely ex-pressed in brain and upregulated in endothelial cells in response to inflammatory signals, such as LPS, IL-1, TNF and CD40L. Fractalkine exists both as a membrane-bound form and as a chemotactic soluble form, and binds its cognate receptor, CX3CR1, with high affinity, to induce leukocyte adhesion and migration or chemotactic functions. CX3CR1, previously designated V28 and chemokine β receptor-like 1 (CMKBRL1), is expressed in neutrophils, monocytes, T lymphocytes and several organs including brain. CX3CR1 also functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. CX3CR1 may also be involved in the pathogenesis of atherosclerotic coronary artery disease (CAD) and is considered a potential drug target for therapeutic intervention of endothelium-related inflammatory diseases.

Specificity:

CX3CR1 polyclonal antibody detects endogenous levels of CX3CR1 protein.

Alternative names:

CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28; CX3CR1; CMKBRL1; GPR13

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human CX3CR1

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 44 kDa

Applications:

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com