Background:

APC (adenomatous polyposis coli) is a tumor suppressor gene that is frequently mutated in colorectal cancers and is one of the earliest indicators of colorectal carcinogenesis. APC is widely expressed and is largely similar to the related brain-specific homolog APCL. These proteins both associate with β-catenin and functionally regulate the levels of intracellular β-catenin. Additionally, these homologs interact with the microtubule cytoskeletal protein EB1 to regulate cell cycle progression or growth control. EB1 family proteins (EB1, RP1 (EB2) and EB3) interact with cytoplasmic microtubules ininterphase cells, with mitotic spindles, and with the APC tumor suppressor gene. The functional inactivation of the APC gene product is a key event in colorectal tumorigenesis. RP1 is localized in the plus ends of microtubule networks in the presence or absence of APC. The gene which encodes RP1 maps to human chromosome 18q12.1.

Specificity:

MAPRE2 polyclonal antibody detects endogenous levels of MAPRE2 protein.

Alternative names:

Microtubule-associated protein RP/EB family member 2; APC-binding protein EB2; End-binding protein 2; EB2; MAPRE2; RP1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human MAPRE2

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 37 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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