MYH9 polyclonal antibody BS60434
Specifications
| 50ul/100ul |
Background:
Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of 2 heavy chains (MHC) and 4 light chains (MLC) that interacts with actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Myosin heavy chain 9 can also be designated Myosin IIa, nonmuscle myosin heavy chain IIa, Cellular myosin heavy chain, type A, myosin-9 or NMMHC-IIA. Myosin heavy chain 9 is involved in cell shape, cytokinesis, and specialized functions such as capping and secretion. It is expressed in leukoctyes and in kidney glomeruli. Defects in the MYH9 gene, which encodes myosin heavy chain 9, are linked to Sebastian syndrome (SBS), Fechtner syndrome (FTNS), Alport syndrome with macrothrombocytopenia (APSM), autosomal dominant nonsyndromic sensorineural deafness 17 (DFNA17) and Epstein syndrome (EPS).
Specificity:
MYH9 polyclonal antibody detects endogenous levels of MYH9 protein.
Alternative names:
Myosin-9; Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle Iia; Non-muscle myosin heavy chain A; NMMHC-A; Non-muscle myosin heavy chain Iia; NMMHC II-a; NMMHC-IIA; MYH9
Species reactivity:
Human,Rat
Host:
Rabbit
Ig type:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Immunogen:
A synthetic peptide corresponding to residues in Human MYH9.
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Molecular weight:
~ 230 kDa
Applications:
WB
Usage:
WB: 1:500~1:1000
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com
