Background:

Cristae are highly folded inner mitochondrial membrane compartments that are studded with cytochromes and ATP synthase proteins and function to provide a large surface area upon which cellular respiration can occur. Mitofilin, also known as IMMT, HMP, PIG4 or P87/89, is a 758 amino acid inner mitochondrial membrane protein that is preferentially expressed in heart tissue. Existing as three alternatively spliced isoforms, Mitofilin functions to control mitochondrial cristae morphology, including the formation and organization of cristae junctions and normal tubular cristae. Due to its role in mediating cristae structure and function, Mitofilin is essential for normal mitochondrial function and is, thus, critical to overall cell survival.

Specificity:

Mitofilin polyclonal antibody detects endogenous levels of Mitofilin protein.

Alternative names:

Mitochondrial inner membrane protein; Cell proliferation-inducing gene 4/52 protein; Mitofilin; p87/89; IMMT; HMP; MINOS2; PIG4; PIG52

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human Mitofilin.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 84 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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