Background:

The Keratin multigene family is made of “soft” epithelial cytokeratins and “hard” hair Keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair Keratins are responsible for creating nails and hair. There are two types of Keratins: the acidic class I Keratin proteins and the basic/neutral class II Keratin proteins. Keratin 84, also known as KRT84, HB4 or KRTHB4, is a 600 amino acid protein that is expressed in hair follicles. Keratin 84 is a basic/neutral type II Keratin protein which heterodimerizes with type I Keratins to create hair and nails. The gene encoding Keratin 84 maps to human chromosome 12 which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis and Kniest dysplasia.

Specificity:

Cytokeratin 84 polyclonal antibody detects endogenous levels of Cytokeratin 84 protein.

Alternative names:

Cytokeratin-84; Keratin, type II cuticular Hb4; Keratin-84; Keratin84; Short name=K84; Type II hair keratin Hb4; Type-II keratin Kb24; KRT84; KRTHB4

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human Cytokeratin 84.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 65 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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