Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF25 (Zinc finger protein 25), also known as Zinc finger protein KOX19, is a 456 amino acid nuclear protein that contains one KRAB domain and twelve C2H2-type zinc fingers. The gene encoding ZNF25 maps to a region of human chromosome 10 that has been a loci of interest for multiple endocrine neoplasia type 2A and 2B. There are two isoforms of ZNF25 that are produced as a result of alternative splicing events.

Specificity:

ZNF25 polyclonal antibody detects endogenous levels of ZNF25 protein.

Alternative names:

Zinc finger protein 25; Zinc finger protein KOX19; KOX19

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human ZNF25.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 90 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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