Background:

Protein kinases catalyze the post-translational transfer of a phosphate group from ATP to a serine, threonine or tyrosine residue, thereby playing a major role in many intracellular and intercellular signaling cascades. STK31 (Serine/threonine-protein kinase 31) is a 1019 amino acid protein belonging to the protein kinase superfamily. STK31 contains one C-terminal protein kinase domain and one N-terminal Tudor domain, which functions as a protein-protein interaction motif during RNA metabolism or transport. As a testis-specific kinase, STK31 is found in both post-meitoic spermatocytes as well as in mature spermatozoa and is thought to be involved in spermatogensis and/or sperm function. Also, as a result of frequent expression in colorectal, gastric and esophageal cancers, STK31 has been identified as a potential cancer/testis (CT) antigen. There are two named isoforms of STK31 which are produced as a result of an alternative splicing event.

Specificity:

STK31 polyclonal antibody detects endogenous levels of STK31 protein.

Alternative names:

Serine/threonine-protein kinase 31; Serine/threonine-protein kinase NYD-SPK; Sugen kinase 396; SgK396; SGK396

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human STK31.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 116 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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