Background:

The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. The human gene that encodes RGS17 (regulator of G protein signaling 17, RGS17) contains 4 exons, spans more than 33 kb and maps to chromosome 6q25.3; the mouse Rgs17 gene maps to chromosome 10 as determined by interspecific backcross mapping. RGS17 is a member of the RZ/A protein family. RZ/A proteins have a simple structure that consists of a conserved amino-terminal cysteine string motif, RGS box and short carboxyl-terminal, which confer GAP activity and the ability to undergo covalent modification and associate with other proteins (at their amino-termini).

Specificity:

RGS17 polyclonal antibody detects endogenous levels of RGS17 protein.

Alternative names:

Regulator of G-protein signaling 17; RGS17

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human RGS17.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 18 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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