Background:

Myosins are molecular motors that move along filamentous Actin and influence cellular movements such as phagocytosis. There are seven classes of myosins in vertebrates, including Myosin II, and six unconventional Myosin classes, designated I, V, VI, VII, IX and X. Myosin VIIa is a plus end-directed motor that influences cilia formation and cell adhesion. Mutations in the human Myosin VIIa gene correlate with Usher syndrome, a disease characterized by congenital sensorineural deafness, vestibular dysfunction and retinitis pigmentosa.

Specificity:

Myosin VIIa polyclonal antibody detects endogenous levels of Myosin VIIa protein.

Alternative names:

Unconventional myosin-VIIa; MYO7A; USH1B

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human Myosin VIIa.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 254 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com