Background:

CIB4 (calciumand integrin-binding familymember 4) is a 185 amino acid protein thatcontainsthree EF-hand domains. CIB4 is closelyrelated to CIB (CIB has one less EF-hand domain),which isknown to bind to IntegrinαIIβ in platelets and isinvolved in signal transduction. The gene encoding CIB4mapsto human chromosome 2,which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare andmorbid skin deformity, is associatedwithmutationsin the ABCA12 gene,while the lipidmetabolic disordersitosterolemia is associated with defectsin the ABCG5 and ABCG8 genes. Additionally, an extremelyrare recessive genetic disorder, Alströmsyndrome, iscaused bymutationsin the ALMS1 gene,whichmaps to chromosome 2.

Specificity:

CIB4 polyclonal antibody detects endogenous levels of CIB4 protein.

Alternative names:

Calcium and integrin-binding family member 4; CIB4

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human CIB4.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 22 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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