Background:

ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes. Ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver and placenta, ABCA5 is a multi-pass membrane protein that contains two ABC transporter domains and exists as three alternatively spliced isoforms. ABCA5 exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site. ABCA5 is the first of five ABC1 family members that maps to human chromosome 17q24. ABCA5 is linked to lysosomal diseases and may play a role in tumor development and cardiomyocyte and follicular cell activities. ABCA5 might also be a specific urine marker for diagnosis of patients with high-grade prostatic intraepithelial neoplasia (HGPIN).

Specificity:

ABCA5 polyclonal antibody detects endogenous levels of ABCA5 protein.

Alternative names:

ATP-binding cassette sub-family A member 5; KIAA1888

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human ABCA5.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 186 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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Email: info@sobekbio.com

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