Background:

Zinc is an essential cofactor that is involved in cell growth and development, as well as in protein, nucleic acid and lipid metabolism. The transport of zinc across the cell membrane is crucial for correct enzyme and overall cell function. ZIP7, also known as SLC39A7 (solute carrier family 39 (zinc transporter), member 7), KE4, HKE4, RING5 or H2-KE4, is a 469 amino acid multi-pass membrane protein that belongs to the ZIP transporter family. Expressed at high levels in kidney, placenta, pancreas and lung, ZIP7 functions as a zinc transporter that facilitates the movement of zinc, both from the extracellular environment and from intracellular storage compartments, to the cytosol. The gene encoding ZIP7 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.

Specificity:

SLC39A7 polyclonal antibody detects endogenous levels of SLC39A7 protein.

Alternative names:

Zinc transporter SLC39A7; Histidine-rich membrane protein Ke4; Really interesting new gene 5 protein; Solute carrier family 39 member 7; Zrt-, Irt-like protein 7; ZIP7; HKE4; RING5

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 179-224 of Human SLC39A7.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 50 kDa

Applications:

WB ICC

Usage:

WB: 1:500~1:1000 ICC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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