Background:

SCG10, also designated stathmin-like 2 (STMN2), is a neuronal growth-associated protein (nGAP) that belongs to the stathmin family. Stathmin family phosphoproteins are involved in regulation of microtubule dynamics and signal transduction. SCG10, which is membrane- associated and neuron-specific, may participate in neuronal differentiation and may modulate membrane interaction with the cytoskeleton during neurite outgrowth. The SCG10 protein binds to and inhibits the assembly of microtubules, and can also induce microtubule disassembly. The assembly and disassembly of microtubules is necessary for cell division, intracellular transport and cell movements, as well as neurite elongation, outgrowth and branching in the developing nervous system.

Specificity:

STMN2 polyclonal antibody detects endogenous levels of STMN2 protein.

Alternative names:

Stathmin-2; Stathmin 2; Stathmin2; Superior cervical ganglion-10 protein; Protein SCG10; SCG10; SCGN10

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 134-179 of Human STMN2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 23 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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