Anti-PSMA7 monoclonal antibody MB62379
Specifications
| 50ul/100ul |
Background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.
Specificity:
proteasome subunit alpha 7
Alternative names:
C6; HEL-S-276; HSPC; RC6-1; XAPC7
Species reactivity:
Human, Mouse, Rat
Host:
Mouse
Ig type:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Immunogen:
Full-length protein expressed in 293T cell transfected with human PSMA7 expression vector
Purification & Purity:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Molecular weight:
27.9 kDa(Predicted)
Applications:
WB
Usage:
WB 1:1000
Storage:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
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