Background:

Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete

Specificity:

catenin beta 1

Alternative names:

armadillo; CTNNB; MRD19

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Ig type:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Immunogen:

Recombinant protein expressed in E.coli corresponding to amino acids 531-781 of human beta-catenin

Purification & Purity:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Molecular weight:

85.3 kDa(Predicted)

Applications:

IF, WB

Usage:

WB 1:1000

Storage:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Precautions:

For research use only, not for use in diagnostic procedure.

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