Background:

The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system. The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13. The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation. The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.

Specificity:

F4/80 Rat monoclonal antibody detects endogenous levels of F4/80 protein.

Alternative names:

ADGRE1, ADGRE1, Adhesion G protein coupled receptor E1, Adhesion G protein-coupled receptor E1, AGRE1, Cell surface glycoprotein EMR1, Cell surface glycoprotein F4/80, DD7A5 7, Egf like module containing mucin like hormone receptor like 1, Egf like module containing mucin like hormone receptor like sequence 1, EGF like module receptor 1, EGF TM7, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EGFTM7, EMR 1, EMR1 hormone receptor, Gpf480, Ly71, Lymphocyte antigen 71, TM7LN3,

Species reactivity:

Human, Mouse

Host:

Rat

Ig type:

Rat IgG in 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Immunogen:

peptide

Purification & Purity:

Immunogen affinity purified

Molecular weight:

160 kDa

Applications:

WB IF IHC(P)

Usage:

WB:1:100-1:1,000 IF:1:50-500 IHC:1:50-500 FC:1μgper1x106cells

Storage:

Store at +4°C

Precautions:

For research use only, not for use in diagnostic procedure.

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