Background:

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.

Specificity:

PTBP1 monoclonal antibody detects endogenous levels of PTBP1 protein.

Alternative names:

PTB, hnRNP I, PTBP1, PTB, 57 kDa RNA binding protein PPTB 1, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, hnRNP I, HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), Polypyrimidine Tract Binding Protein 1, Polypyrimidine tract binding protein, Polypyrimidine tract-binding protein 1, pPTB, PTB 1, PTB 2, PTB 3, PTB 4, PTB, PTB T, PTB1, PTB2, PTB3, PTB4, PTBP 1, PTBP1, PTBP1, PTBT, RNA Binding Protein,

Species reactivity:

Human, Rat

Host:

Mouse

Ig type:

Mouse IgG2a, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human PTBP1 aa 320-550.

Purification & Purity:

ProG affinity purified.

Molecular weight:

57 kDa

Applications:

WB IHC ICC FC

Usage:

WB:1:5,000-1:10,000 IHC:1:50-1:100 ICC:1:50-1:100 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com